CVN293

CAT: 0804-HY-158155-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-158155-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia[1].

CAS Number

2815296-08-1

UNSPSC

12352005

Target

NOD-like Receptor (NLR) ; Potassium Channel

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cvn293.html

Purity

99.91

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NON=C1C2=NC3=CC=CC(F)=C3N2CC4=NN=CC=C4

Molecular Formula

C14H10FN7O

Molecular Weight

311.27

References & Citations

[1]Roland W. Bürli, et al.Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment. ACS Med. Chem. Lett. 2024.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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