ME3221

CAT: 0804-HY-121550-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-121550-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR), with efficacy comparable to or better than losartan in vivo. ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for treating both renal and essential hypertension similarly to losartan[1].

CAS Number

139958-16-0

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/me3221.html

Smiles

COC1=C(C=C(C)N=C1C)OCC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=NN4

Molecular Formula

C22H21N5O2

Molecular Weight

387.43

References & Citations

[1]Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

ME3221

Popular Products