Eprinomectin

• Description :

  Eprinomectin (MK-397) is a type of avermectin. Eprinomectin, as a broad-spectrum fungicide, has insecticidal, insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity[1][2][3].

• Product Name Alternative :

  MK-397

• UNSPSC :

  12352005

• Hazard Statement :

  H225, H302+H312+H332, H319

• Target :

  Apoptosis; Autophagy; Bacterial; Parasite; Reactive Oxygen Species (ROS) ; β-catenin

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/Eprinomectin.html

• Concentration :

  10mM

• Purity :

  98.02

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  C[C@H]1[C@@H](NC(C)=O)[C@@H](OC)C[C@H](O[C@@H]2[C@H](C)O[C@@H](O[C@@H](/C(C)=C/C[C@@H](C3)OC4(O[C@@H]([C@@H](CC)C)[C@H](C)C=C4)C[C@H]3OC5=O)[C@@H](/C=C/C=C6CO[C@@H]7[C@@]\6(O)[C@H]5C=C(C)[C@H]7O)C)C[C@@H]2OC)O1

• Molecular Formula :

  C50H75NO14

• Molecular Weight :

  914.13

• Precautions :

  H225, H302+H312+H332, H319

• References & Citations :

  [1]Shoop WL, et al. Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. Int J Parasitol. 1996 Nov;26 (11) :1237-42.|[2]Samy A, et al. Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway. J Cancer Res Clin Oncol. 2023 Sep;149 (11) :9085-9104.|[3]do Nascimento CG, et al. Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics. J Vet Pharmacol Ther. 2020 Mar;43 (2) :171-178.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Mite

• CAS Number :

  [123997-26-2]