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Eprinomectin

CAT: 0804-HY-12643-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12643-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eprinomectin (MK-397) is a type of avermectin. Eprinomectin, as a broad-spectrum fungicide, has insecticidal, insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity[1][2][3].
CAS Number
123997-26-2
Product Name Alternative
MK-397
UNSPSC
12352005
Hazard Statement
H225, H302+H312+H332, H319
Target
Apoptosis; Autophagy; Bacterial; Parasite; Reactive Oxygen Species (ROS) ; β-catenin
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Eprinomectin.html
Concentration
10mM
Purity
98.02
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C[C@H]1[C@@H](NC(C)=O)[C@@H](OC)C[C@H](O[C@@H]2[C@H](C)O[C@@H](O[C@@H](/C(C)=C/C[C@@H](C3)OC4(O[C@@H]([C@@H](CC)C)[C@H](C)C=C4)C[C@H]3OC5=O)[C@@H](/C=C/C=C6CO[C@@H]7[C@@]\6(O)[C@H]5C=C(C)[C@H]7O)C)C[C@@H]2OC)O1
Molecular Formula
C50H75NO14
Molecular Weight
914.13
Precautions
H225, H302+H312+H332, H319
References & Citations
[1]Shoop WL, et al. Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. Int J Parasitol. 1996 Nov;26 (11) :1237-42.|[2]Samy A, et al. Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway. J Cancer Res Clin Oncol. 2023 Sep;149 (11) :9085-9104.|[3]do Nascimento CG, et al. Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics. J Vet Pharmacol Ther. 2020 Mar;43 (2) :171-178.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mite

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