MS049

• Description:

  MS049, a chemical probe, is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MS049.html

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 31 mg/mL|H2O : ≥ 100 mg/mL

• Smiles:

  CNCCN1CCC(OCC2=CC=CC=C2)CC1

• Molecular Formula:

  C15H24N2O

• Molecular Weight:

  248.36

• Precautions:

  H301

• References & Citations:

  [1]Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PRMT4; PRMT6; PRMT8

• CAS Number:

  [1502816-23-0]