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Savolitinib

CAT: 0607-BA8873-10Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0607-BA8873-10Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1313725-88-0
Form
A solid
Molecular Formula
C17H15N9
Molecular Weight
345.36
Shipping Conditions
Blue ice
Storage Conditions
-20°C.

Chemical Information

Savolitinib

Savolitinib is a member of the class of triazolopyrazines that is 1H-[1,2,3]triazolo[4,5-b]pyrazine substituted by (1S)-1-(imidazo[1,2-a]pyridin-6-yl)ethyl and 1-methyl-1H-pyrazol-4-yl groups at positions 1 and 6, respectively. It is a highly selective MET tyrosine kinase inhibitor that is approved in China for advanced NSCLC with MET exon 14 skipping mutations. It has a role as an antineoplastic agent and a c-Met tyrosine kinase inhibitor. It is a member of pyrazoles, an imidazopyridine and a triazolopyrazine.

CAS Number1313725-88-0
PubChem CID68289010
IUPAC Name3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine
Molecular FormulaC17H15N9
Molecular Weight345.4
XLogP1.5
Topological Polar Surface Area91.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity505
SMILES
C[C@@H](C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C
InChI
InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
InChIKey
XYDNMOZJKOGZLS-NSHDSACASA-N
Chemical Structure
2D Structure
2D structure of Savolitinib
CAS: 1313725-88-0
CID: 68289010
Formula: C17H15N9
MW: 345.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.4
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass345.14504152
Monoisotopic Mass345.14504152
Topological Polar Surface Area91.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity505
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-15959-01Savolitinib
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