Py-MAA-Val-Cit-PAB-MMAE

Py-MAA-Val-Cit-PAB-MMAE

• CAS Number: 2247398-68-9
• UNSPSC Description: Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors[1][2][3].
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/py-maa-val-cit-pab-mmae.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CSCCC(N4CN(CN(C4)C(C=C)=O)C(C=C)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
• Molecular Weight: 1446.79
• References & Citations: [1]Zheng Dexia, et al. Anti-tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAILR2) antibody-drug conjugate (ADC) and its pharmaceutical application in antineoplastic therapy: China, CN108452320. 2018-08-28. |[2]Fang, et al. Anti-c-Met antibody drug conjugates and their applications. TWI817190B. 2023.10.01|[3]Fang, et al. Anti-mesothelin antibody and antibody-drug conjugate thereof. WO2019223579A1. 2019-11-28.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported