PTACH

• Description :

  PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 μM) [1][2].

• CAS Number :

  [848354-66-5]

• Product Name Alternative :

  NCH-51

• UNSPSC :

  12352005

• Hazard Statement :

  H318, H413

• Target :

  HDAC; HIV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/PTACH.html

• Purity :

  99.65

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O

• Molecular Formula :

  C20H26N2O2S2

• Molecular Weight :

  390.56

• Precautions :

  H318, H413

• References & Citations :

  [1]Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48 (4) :1019-1032.|[2]Ann Florence B Victoriano, et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett. 2011 Apr 6;585 (7) :1103-11.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC4; HDAC6; HIV-1