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MDL-800

CAT: 0026-B2760-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2760-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDL-800 is a potent and selective allosteric activator (EC50 = 10.3 µM) of SIRT6, a member of the SIRT deacetylase family. Does not display any activities toward SIRT1, SIRT3, SIRT4 and HDAC1-11 at concentrations up to 50 μM or 100 μM. MDL-800 increases the deacetylase activity of SIRT6 by up to 22-fold resulting in a decrease in H3K9Ac and H3K56Ac in hepatocellular carcinoma (HCC) cells, causing cell cycle arrest and inhibiting their proliferation.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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