Recombinant Human Nascent polypeptide-associated complex subunit alpha (NACA)

CAT: 0399-CSB-YP623830HUb0-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0399-CSB-YP623830HUb0-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Product Name Alternative

Alpha-NAC (Allergen: Hom s 2) (NAC-alpha)

Abbreviation

Recombinant Human NACA protein

Gene Name

NACA

UniProt

Q13765

Expression Region

1-215aa

Organism

Homo sapiens (Human)

Target Sequence

MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM

Tag

N-terminal 10xHis-tagged

Type

Developed Protein

Source

Yeast

Field of Research

Epigenetics and Nuclear Signaling

Relevance

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum. Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle, which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane. May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

Endotoxin

Not test

Purity

Greater than 90% as determined by SDS-PAGE.

Activity

Not Test

Form

Liquid or Lyophilized powder

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Molecular Weight

25.9 kDa

References & Citations

"Investigation of alpha nascent polypeptide-associated complex functions in a human CD8 (+) T cell ex vivo expansion model using antisense oligonucleotides." Al-Shanti N., Steward C.G., Garland R.J., Rowbottom A.W. Immunology 112:397-403 (2004)

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Protein Length

Full Length

UniProtKB · Q13765

Nascent polypeptide-associated complex subunit alpha

NACA_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q13765
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NACA
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: NAC-alpha
EC number: —
Processing: —
Secondary accessions: A8MTN7, B2R4P8, F8VU71, Q3KQV4, Q53A18, Q53G46

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Disease

Allergen

Coding sequence diversity

Alternative splicing

Molecular function

ChaperoneDNA-binding

Cellular component

CytoplasmNucleus

Biological process

Protein transportTranscriptionTransport

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Alternative Products

Catalog	Name
abx136032-01	Nascent Polypeptide-Associated Complex Alpha Subunit (NACA) Antibody
328986-01	NACA, phosphorylated (S43) (NACA, HSD48, Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC)
341500-01	NACA, phosphorylated (S43) (NACA, HSD48, Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC) discontinued
abx261517-01	Human Nascent Polypeptide-Associated Complex Alpha Subunit (NACA) Peptide
MBS7135849-01	Recombinant Human Nascent polypeptide-associated complex subunit alpha (NACA)
MBS1341099-01	Recombinant Mouse Nascent polypeptide-associated complex subunit alpha (Naca)
MBS1319180-01	Recombinant Bovine Nascent polypeptide-associated complex subunit alpha (NACA)
MBS1366941-01	Recombinant Danio rerio Nascent polypeptide-associated complex subunit alpha (naca)
MBS1449308-01	Recombinant Oreochromis niloticus Nascent polypeptide-associated complex subunit alpha (naca)
MBS1476189-01	Recombinant Dictyostelium discoideum Nascent polypeptide-associated complex subunit alpha (nacA)