dBRD4-BD1
CAT:
804-HY-151593-03
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
dBRD4-BD1
- CAS Number: 2839318-19-1
- UNSPSC Description: dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].
- Target Antigen: Epigenetic Reader Domain; PROTACs
- Type: Reference compound
- Related Pathways: Epigenetics;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/dbrd4-bd1.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCC(NCCOCCOCCN4CCC(CC4)N5C=NC(C6=CC=C(C(F)(F)F)C=C6)=C5C7=CC=NC(OC8=CC(C(C)C)=CC=C8C)=N7)=O)=CC=C3)=O)=O
- Molecular Weight: 967.00
- References & Citations: [1]Divakaran A, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported