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Rolofylline

CAT: 0804-HY-10965-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10965-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450) [1]. Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases[2].
CAS Number
136199-02-5
Product Name Alternative
KW-3902
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rolofylline.html
Purity
99.68
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(N1CCC)N(CCC)C2=C(N=C(C34CC(C5)CC3CC5C4)N2)C1=O
Molecular Formula
C20H28N4O2
Molecular Weight
356.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Stroh M, et al. Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites. AAPS J. 2013 Apr;15 (2) :498-504.|[2]Dennissen FJ, et al. Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280. Proc Natl Acad Sci U S A. 2016 Oct 11;113 (41) :11597-11602. Epub 2016 Sep 26.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

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MBS3601492Rolofylline
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A21649-10Rolofylline 10mg
A21649-100Rolofylline 100mg
A21649-25Rolofylline 25mg
A21649-1Rolofylline 1mg
A21649-5Rolofylline 5mg
A21649-10mM-DRolofylline 10mM * 1mL in DMSO
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