Morroniside

CAT: 0804-HY-N0532-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N0532-02Size:10 mg

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Description

Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

CAS Number

25406-64-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; MMP; Pyroptosis

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Morroniside.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@H]3C)([H])[C@@](C[C@H](O)O3)([H])C(C(OC)=O)=CO2

Molecular Formula

C17H26O11

Molecular Weight

406.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Zeng G, et al. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16 (3) :2229-2234.|[2]Park CH, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34 (10) :1559-65.|[3]Huan Yu, et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10;266:113447.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

MMP-2; MMP-9

Chemical Information

Morroniside

Morroniside is a glycoside.

CAS Number	25406-64-8
PubChem CID	11228693
IUPAC Name	methyl (1S,3R,4aS,8S,8aS)-3-hydroxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylate
Molecular Formula	C17H26O11
Molecular Weight	406.4
XLogP	-1.8
Topological Polar Surface Area	164
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	5
Heavy Atom Count	28
Formal Charge	0
Complexity	596

SMILES

C[C@H]1[C@@H]2[C@H](C[C@@H](O1)O)C(=CO[C@H]2O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)OC

InChI

InChI=1S/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9+,10+,11+,12+,13-,14+,16-,17-/m0/s1

InChIKey

YTZSBJLNMIQROD-SFBCHFHNSA-N

Chemical Structure

2D Structure

CAS: 25406-64-8

CID: 11228693

Formula: C17H26O11

MW: 406.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	406.4
XLogP3	-1.8
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	5
Exact Mass	406.14751164
Monoisotopic Mass	406.14751164
Topological Polar Surface Area	164 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	596
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
TB0500-0020	Morroniside

Morroniside

Chemical Information

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