Products for Research Use Only
RegisterLogin

UR778Br

CAT: 0804-HY-163707-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-163707-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
UR778Br targets the GTPase-activating protein-related domain (GRD domain) of IQGAP1 proteins. UR778Br inhibits the proliferation of human acute myeloid leukemia (AML), arrests the cell cycle at the G2/M phase, and induces apoptosis. UR778Br inhibits colony formation of primary and AML cells, without significant impacts on normal bone marrow cells[1].
CAS Number
866127-80-2
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ur778br.html
Purity
99.33
Solubility
DMSO : 14 mg/mL (ultrasonic)
Smiles
CCCCN1C(C(CC(C2=CC=CC=C2O)=O)(C3=C1C=CC(Br)=C3)O)=O
Molecular Formula
C20H20BrNO4
Molecular Weight
418.28
References & Citations
[1]Sahasrabudhe DM, et al., In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia. Sci Rep. 2024 Jun 4;14 (1) :12868.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T88760-01UR778Br

Popular Products