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Chloroprocaine

CAT: 0804-HY-B1604ASize: 1 EachDry Ice: NoHazardous: No
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Description
Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of Na, K-ATPase activity with an IC50 of 13 mM. Chloroprocaine blocks peripheral nerve[1].
CAS Number
133-16-4
Product Name Alternative
2-Chloroprocaine
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Na+/K+ ATPase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chloroprocaine.html
Solubility
10 mM in DMSO
Smiles
CCN(CCOC(C1=C(Cl)C=C(N)C=C1)=O)CC
Molecular Formula
C13H19ClN2O2
Molecular Weight
270.76
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]H Kutchai, et al. Inhibition of the Na, K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43 (4) :399-403.|[2]Chloroprocaine HCl Injection.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Chloroprocaine

Chloroprocaine is procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. It has a role as a central nervous system depressant, a local anaesthetic and a peripheral nervous system drug. It is a benzoate ester and a member of monochlorobenzenes. It is functionally related to a 2-diethylaminoethanol and a 4-amino-2-chlorobenzoic acid.

CAS Number133-16-4
PubChem CID8612
IUPAC Name2-(diethylamino)ethyl 4-amino-2-chlorobenzoate
Molecular FormulaC13H19ClN2O2
Molecular Weight270.75
XLogP2.9
Topological Polar Surface Area55.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Heavy Atom Count18
Formal Charge0
Complexity259
SMILES
CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl
InChI
InChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
InChIKey
VDANGULDQQJODZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Chloroprocaine
CAS: 133-16-4
CID: 8612
Formula: C13H19ClN2O2
MW: 270.75
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight270.75
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass270.1135055
Monoisotopic Mass270.1135055
Topological Polar Surface Area55.6 Ų
Heavy Atom Count18
Formal Charge0
Complexity259
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS5803198Chloroprocaine
B4870-25Chloroprocaine HCl
444426-01Chloroprocaine Hydrochloride
AR-A06105-01Chloroprocaine DiHCl

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