Tolafentrine

CAT: 0804-HY-W700639-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0804-HY-W700639-01Size:500 µg

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Description

Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes[1].

CAS Number

139308-65-9

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tolafentrine.html

Smiles

[H][C@@]12CN(CC[C@@]1(N=C(C3=C2C=C(C(OC)=C3)OC)C4=CC=C(C=C4)NS(C5=CC=C(C=C5)C)(=O)=O)[H])C

Molecular Formula

C28H31N3O4S

Molecular Weight

505.63

References & Citations

[1]Schermuly RT, et al. Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension. Circ Res. 2004 Apr 30;94 (8) :1101-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Tolafentrine

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