Abemaciclib metabolite M2
CAT:
804-HY-128669-01
Size:
100 mg
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Abemaciclib metabolite M2
- Product Name Alternative: LSN2839567
- CAS Number: 1231930-57-6
- UNSPSC Description: Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].
- Target Antigen: CDK; Drug Metabolite
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/abemaciclib-metabolites-m2.html
- Purity: 99.94
- Solubility: DMSO : 2 mg/mL (ultrasonic)
- Smiles: CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C
- Molecular Weight: 478.54
- References & Citations: [1]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).|[2]CHMP. Assessment report Verzenios. 26 July 2018 EMA/551438/2018.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported