HBP08

CAT: 0804-HY-P10321Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10321Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HBP08 is a selective inhibitor of CXCL12/HMGB1 interaction. HBP08 has a high affinity for HMGB1 (Kd=0.8 μM) . HBP08 inhibits CXCL12-mediated cell migration[1].
CAS Number
[2490442-13-0]
UNSPSC
12352209
Target
CXCR
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hbp08.html
Solubility
10 mM in DMSO
Smiles
OC([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC2=CC=C(C=C2)O)=O)CC3=CN=CN3)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O
Molecular Formula
C60H77N17O14
Molecular Weight
1260.36
References & Citations
[1]Sgrignani J, et al. Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction. J Med Chem. 2021 Sep 23;64 (18) :13439-13450.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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CatalogName
MF-0126428-01HBP08

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