CCND1 Polyclonal Antibody

CAT: 0763-AN006770L-01Size: 25 µLDry Ice: NoHazardous: No

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CAT#:0763-AN006770L-01Size:25 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Abbreviation

CCND1

UniProt

P24385

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Human CCND1 protein expressed by E.coli

Target

Cyl; PRAD; U21B; CCND; B cell leukemia; G1/S specific cyclin D; Cyclin D; BCL; BCL1; D11S287E; PRAD1; U21B31; CCND1; Cyclin D1; B cell leukemia 1; BCL 1; Cd1; Cyl 1; G1/S specific cyclin D1; BCL1; D11S287E; PRAD1; U21B31; CCND1; Cyclin D1; cyclin D1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Field of Research

Cell Biology; Epigenetics and Nuclear Signaling; Cancer

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000

Buffer

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

34 kDa

Observed Molecular Weight

35 kDa

Isotype

IgG

UniProtKB · P24385

G1/S-specific cyclin-D1

CCND1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P24385
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CCND1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q6LEF0

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Cell cycleCell divisionDNA damageTranscriptionTranscription regulation

Coding sequence diversity

Chromosomal rearrangement

Molecular function

CyclinRepressor

Cellular component

CytoplasmMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Disease

Proto-oncogene

Product Datasheet

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