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Caracemide

CAT: 0804-HY-119974-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119974-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity[1][2].
CAS Number
81424-67-1
Product Name Alternative
NSC-253272
UNSPSC
12352211
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/caracemide.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N(OC(NC)=O)C(NC)=O)=O
Molecular Formula
C6H11N3O4
Molecular Weight
189.17
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Larsen IK, et al. Caracemide, a site-specific irreversible inhibitor of protein R1 of Escherichia coli ribonucleotide reductase. J Biol Chem. 1992 Jun 25;267 (18) :12627-31.|[2]Slatter JG, et al. Studies on the metabolic fate of caracemide, an experimental antitumor agent, in the rat. Evidence for the release of methyl isocyanate in vivo. Chem Res Toxicol. 1993 May-Jun;6 (3) :335-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA1574-5Caracemide

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