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RH12

CAT: 0804-HY-162719Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162719Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RH12 is a dual inhibitor for SARS-CoV-2 related RNA-dependent RNA polymerase (RdRp, IC50 is 4.42 nM) and human transmembrane serine protease 2 (TMPRSS2, IC50 is 4.2 nM) . RH12 exhibits antiviral efficacy. RH12 inhibits viral replication and absorption, and exhibits a 90.5% virucidal effects on Vero-E6 cells. RH12 inhibits cell viability of Calu-3 with an IC50 of 17.5 nM[1].
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rh12.html
Smiles
N=C(N)NC1=CC=C(C(OC2=CC=C(OC(C=C3C(C)C)=O)C3=C2)=O)C=C1
Molecular Formula
C20H19N3O4
Molecular Weight
365.38
References & Citations
[1]Soliman SSM, et al., Novel compounds with dual inhibition activity against SARS-CoV-2 critical enzymes RdRp and human TMPRSS2. Eur J Med Chem. 2024 Jul 11;276:116671.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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