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Amphomycin

CAT: 0804-HY-P3078Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3078Size:1 mg
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Description
Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3].
CAS Number
1402-82-0
UNSPSC
12352209
Target
Antibiotic; Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/amphomycin.html
Purity
96.30
Solubility
10 mM in DMSO
Smiles
O=C([C@]1([H])CCCN1C([C@@H](NC([C@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@]2([H])CCCCN2C3=O)=O)[C@H](C)C(O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)[C@@H](C)N)=O)C(C)C)=O)N[C@@H]([C@@H]3NC([C@H](CC(O)=O)NC(C/C=C\CCCCCC(CC)C)=O)=O)C
Molecular Formula
C58H91N13O20
Molecular Weight
1290.42
References & Citations
[1]Singh M, et al. Solid-state NMR characterization of amphomycin effects on peptidoglycan and wall teichoic acid biosyntheses in Staphylococcus aureus. Sci Rep. 2016 Aug 19;6:31757. |[2]Pasetka CJ, et al. Novel antimicrobial lipopeptides with long in vivo half-lives. Int J Antimicrob Agents. 2010 Feb;35 (2) :182-5. |[3]Tanaka H, et al. Amphomycin inhibits phospho-N-acetylmuramyl-pentapeptide translocase in peptidoglycan synthesis of Bacillus. Biochem Biophys Res Commun. 1979 Feb 14;86 (3) :902-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Lipopeptide

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