YU238259

• Description :

  YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.

• CAS Number :

  [1943733-16-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  DNA-PK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/YU238259.html

• Concentration :

  10mM

• Purity :

  98.56

• Solubility :

  DMSO : 110 mg/mL (ultrasonic)

• Smiles :

  COC1=CC=C(S(NCC2=CC=C(C(NCCC3=CC=C(Cl)C=N3)=O)C=C2)(=O)=O)C=C1

• Molecular Formula :

  C22H22ClN3O4S

• Molecular Weight :

  459.95

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Stachelek GC, et al. YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors. Mol Cancer Res. 2015 Oct;13 (10) :1389-97.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported