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YU238259

CAT: 0804-HY-19977-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19977-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.
CAS Number
1943733-16-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/YU238259.html
Concentration
10mM
Purity
98.56
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
COC1=CC=C(S(NCC2=CC=C(C(NCCC3=CC=C(Cl)C=N3)=O)C=C2)(=O)=O)C=C1
Molecular Formula
C22H22ClN3O4S
Molecular Weight
459.95
Precautions
H302, H315, H319, H335
References & Citations
[1]Stachelek GC, et al. YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors. Mol Cancer Res. 2015 Oct;13 (10) :1389-97.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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