BCN-PEG4-NHS ester

• Description :

  BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bcn-peg4-nhs-ester.html

• Purity :

  95.0

• Solubility :

  10 mM in DMSO

• Smiles :

  [H][C@@]12[C@@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O)=O

• Molecular Formula :

  C26H38N2O10

• Molecular Weight :

  538.59

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]"An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. "

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Alkyl/ether Linkers; PEG Linkers