BCN-PEG4-NHS ester

• Description:

  BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Linker; PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bcn-peg4-nhs-ester.html

• Purity:

  95.0

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@@]12[C@@] (CCC#CCC2) ([H]) [C@@H]1COC (NCCOCCOCCOCCOCCC (ON3C (CCC3=O) =O) =O) =O

• Molecular Formula:

  C26H38N2O10

• Molecular Weight:

  538.59

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]"An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. "

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Alkyl/ether Linkers; PEG Linkers