Polydextrose

• Description :

  Polydextrose is an orally active prebiotic. Polydextrose promotes the growth of Pediococcus pentosaceus ATCC 43200. Polydextrose reduces cholesterol and synergistically lowers blood sugar with Sitagliptin (HY-13749) . Currently, it is mainly used in the research of diseases such as hyperlipidemia, type 2 diabetes, and postoperative iron deficiency anemia[1][2][3][4][5].

• CAS Number :

  [68424-04-4]

• UNSPSC :

  12352200

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Bacterial

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection; Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/polydextrose.html

• Purity :

  95.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]1CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O.[n]

• Molecular Formula :

  (C12H22O11) n

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Pronczuk A, et al. Hypocholesterolemic effect of dietary polydextrose in gerbils and humans[J]. Nutrition Research, 2006, 26 (1) : 27-31.|[2]Mäkeläinen HS, et al. The effects of polydextrose and xylitol on microbial community and activity in a 4-stage colon simulator. J Food Sci. 2007 Jun;72 (5) :M153-9.|[3]Wanderley Porto MC, et al. Effect of Polydextrose on the Growth of Pediococcus pentosaceus as Well as Lactic Acid and Bacteriocin-like Inhibitory Substances (BLIS) Production. Microorganisms. 2022 Sep 24;10 (10) :1898.|[4]do Carmo MMR, et al. Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats. Nutrients. 2018 Jun 20;10 (6) :792.|[5]Stenman LK, et al. Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice. Diabetol Metab Syndr. 2015 Sep 12;7:75.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  Phase 2