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Vialinin A

CAT: 0804-HY-103435-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103435-01Size:1 mg
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Description
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1) . Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke[1][2][3].
CAS Number
858134-23-3
Product Name Alternative
Terrestrin A
UNSPSC
12352005
Target
Deubiquitinase; E1/E2/E3 Enzyme; Keap1-Nrf2; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vialinin-a.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC=CC=C1)OC2=C(C(C3=CC=C(C=C3)O)=C(C(O)=C2C4=CC=C(O)C=C4)O)OC(CC5=CC=CC=C5)=O
Molecular Formula
C34H26O8
Molecular Weight
562.57
References & Citations
[1]Ji-Kai Liu, et al. Natural terphenyls: developments since 1877. Chem Rev. 2006 Jun;106 (6) :2209-23.|[2]Jie Xu, et al. Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.J Cell Mol Med. 2021 Jan;25 (2) :1140-1150. |[3]Himangshu Sonowal, et al. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxid Med Cell Longev. 2018 Feb 6;2018:1052102.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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IJB13423-01Vialinin A
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A15321-100Vialinin A 100mg
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A15321-50Vialinin A 50mg
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