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LY288513

CAT: 0804-HY-103357-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103357-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY288513 is a selective non-peptide CCK-B receptor antagonist with an IC50 value of 16 nM. LY288513 produces an anxiolytic-like action in mice[1][2][3].
CAS Number
147523-65-7
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly288513.html
Solubility
10 mM in DMSO
Smiles
O=C(N1NC([C@@H](C2=CC=CC=C2)[C@@H]1C3=CC=CC=C3)=O)NC4=CC=C(Br)C=C4
Molecular Formula
C22H18BrN3O2
Molecular Weight
436.30
References & Citations
[1]Rasmussen K. CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons. Ann N Y Acad Sci. 1994 Mar 23;713:300-11.|[2]Zhang JG, et al. Cholecystokinin octapeptide regulates the differentiation and effector cytokine production of CD4 (+) T cells in vitro. Int Immunopharmacol. 2014;20 (2) :307-315.|[3]Helton DR, et al. Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol Biochem Behav. 1996 Mar;53 (3) :493-502.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCKBR

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CatalogName
T22949-01LY288513

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