Products for Research Use Only
RegisterLogin

Zipalertinib

CAT: 0804-HY-112299-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-112299-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Zipalertinib (TAS6417; CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1.1-8.0 nM[1][2].
CAS Number
1661854-97-2
Product Name Alternative
TAS6417; CLN-081
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zipalertinib.html
Purity
99.62
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC1=C2C(N3C(C(C)=C[C@@H](C3)NC(C=C)=O)=C2C4=CC5=CC=CC=C5N=C4)=NC=N1
Molecular Formula
C23H20N6O
Molecular Weight
396.44
References & Citations
[1]Hasako S, et al. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17 (8) :1648-1658.|[2]Hibiki Udagawa, et al. TAS6417/CLN-081 Is a Pan-Mutation-Selective EGFR Tyrosine Kinase Inhibitor with a Broad Spectrum of Preclinical Activity against Clinically Relevant EGFR Mutations. Mol Cancer Res. 2019 Nov;17 (11) :2233-2243.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
EGFR/ErbB1/HER1

Alternative Products

CatalogName
A4683-5Zipalertinib
C13690-01Zipalertinib (TAS6417)
A19541-2Zipalertinib (TAS6417) 2mg
A19541-1Zipalertinib (TAS6417) 1mg
A19541-10Zipalertinib (TAS6417) 10mg
A19541-500Zipalertinib (TAS6417) 500mg
A19541-100Zipalertinib (TAS6417) 100mg
A19541-50Zipalertinib (TAS6417) 50mg
A19541-5Zipalertinib (TAS6417) 5mg
A19541-25Zipalertinib (TAS6417) 25mg

Popular Products