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LQZ-7I

CAT: 0804-HY-136538-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136538-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors[1].
CAS Number
195822-23-2
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Survivin
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lqz-7i.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(F)C=C4)C=C1
Molecular Formula
C20H14F2N4
Molecular Weight
348.35
Precautions
H302, H315, H320, H335
References & Citations
[1]Robert Peery, et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N2,N3-bis(4-fluorophenyl)quinoxaline-2,3-diamine
CAS Number195822-23-2
PubChem CID468690
IUPAC Name2-N,3-N-bis(4-fluorophenyl)quinoxaline-2,3-diamine
Molecular FormulaC20H14F2N4
Molecular Weight348.3
XLogP5.2
Topological Polar Surface Area49.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity396
SMILES
C1=CC=C2C(=C1)N=C(C(=N2)NC3=CC=C(C=C3)F)NC4=CC=C(C=C4)F
InChI
InChI=1S/C20H14F2N4/c21-13-5-9-15(10-6-13)23-19-20(24-16-11-7-14(22)8-12-16)26-18-4-2-1-3-17(18)25-19/h1-12H,(H,23,25)(H,24,26)
InChIKey
DKPCKOKYSVPFEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N2,N3-bis(4-fluorophenyl)quinoxaline-2,3-diamine
CAS: 195822-23-2
CID: 468690
Formula: C20H14F2N4
MW: 348.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight348.3
XLogP35.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass348.11865279
Monoisotopic Mass348.11865279
Topological Polar Surface Area49.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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