8-Hydroxy guanosine-13C,15N2

• UNSPSC Description:

  8-Hydroxy guanosine-13C,15N2 is 13C and 15N labeled 8-Hydroxyguanosine. 8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of B cells[1][2][3][4].

• Target Antigen:

  Endogenous Metabolite; Isotope-Labeled Compounds

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Others

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/8-hydroxy-guanosine-13c-15n2.html

• Smiles:

  O=C1[15NH][13C]([15NH2])=NC2=C1N=C(N2[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO)O

• Molecular Weight:

  302.22

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ahmad A, et al. 8-Hydroxyguanosine and 8-methoxyguanosine possess immunostimulating activity for B lymphocytes. Cell Immunol. 1985 Aug;94(1):276-80. |[3]Fiala ES, et al. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 1989 Oct 15;49(20):5518-22.|[4]Abe T, et al. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported