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Siegesbeckialide I

CAT: 0804-HY-N10111-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N10111-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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UNSPSC Description
Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.
Target Antigen
IKK
Type
Natural Products
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/siegesbeckialide-i.html
Solubility
10 mM in DMSO
Smiles
C/C=C(C)\C(OC[C@@H]1CC/C=C(CO)\C[C@@H](O)[C@@H]2[C@H](OC(C2=C)=O)C1)=O
Molecular Weight
364.43
References & Citations
[1]Gao X, et al. Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β. J Nat Prod. 2021 Nov 26;84(11):2808-2821.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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T72578-01Siegesbeckialide I

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