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Degrasyn

CAT: 0804-HY-13264-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13264-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.
CAS Number
856243-80-6
Product Name Alternative
WP1130
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Apoptosis; Autophagy; Bcr-Abl; Deubiquitinase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WP1130.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=CC=CC(/C=C(C(N[C@H](C2=CC=CC=C2)CCC)=O)\C#N)=N1
Molecular Formula
C19H18BrN3O
Molecular Weight
384.27
Precautions
H301, H311, H331
References & Citations
[1]Bartholomeusz GA, et al. Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. Blood. 2007 Apr 15;109 (8) :3470-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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