(4S)-PROTAC SOS1 degrader-1 (diTFA)

(4S)-PROTAC SOS1 degrader-1 (diTFA)

• UNSPSC Description: (4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo[1].
• Target Antigen: PROTACs; Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/4s-protac-sos1-degrader-1-ditfa.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)CCCCCCCCN4CCN(CC4)C5=C6N=C(N7CC8(CNC8)C7)N(CC9=CC(C)=C(F)C(C)=C9)C6=CC(Cl)=C5.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
• Molecular Weight: 1279.84
• References & Citations: [1]Zhou C,et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022; 65(5):3923-3942.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported