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ZK159222

CAT: 0804-HY-12397Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-12397Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZK159222, a 25-carboxylic ester analogue of 1α,25- (OH) 2D3, is a potent 1α,25- (OH) 2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character[1].
CAS Number
156965-15-0
UNSPSC
12352211
Target
VD/VDR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/zk159222.html
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1([C@H](O)/C=C/[C@H]([C@H]2CC[C@@]3([H])/C(CCC[C@]23C)=C/C=C4C([C@@H](O)C[C@H](O)C\4)=C)C)CC1)OCCCC
Molecular Formula
C32H48O5
Molecular Weight
512.72
References & Citations
[1]Herdick M, et al. Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. J Biol Chem. 2000 Jun 2;275 (22) :16506-12.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T17292ZK159222

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