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Ditolylguanidine

CAT: 0804-HY-14218-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14218-01Size:500 mg
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Description
Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer[1][2][3][4].
CAS Number
97-39-2
Product Name Alternative
1,3-Di-o-tolylguanidine; DTG
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ditolylguanidine.html
Purity
99.66
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
CC1=C(NC(NC2=CC=CC=C2C)=N)C=CC=C1
Molecular Formula
C15H17N3
Molecular Weight
239.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Shimizu I, et al. Effects of (+) -pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. Br J Pharmacol. 2000 Oct;131 (3) :610-6.|[2]John CS, et al. Sigma receptors are expressed in human non-small cell lung carcinoma. Life Sci. 1995;56 (26) :2385-92.|[3]Moody TW, et al. Sigma ligands inhibit the growth of small cell lung cancer cells. Life Sci. 2000 Apr 7;66 (20) :1979-86.|[4]Moison D, et al. Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo. Neuropharmacology. 2003 Dec;45 (7) :945-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor

Alternative Products

CatalogName
MBS3845698-01Ditolylguanidine
A21268-1000Ditolylguanidine 1g
A21268-500Ditolylguanidine 500mg
A21268-10mM-DDitolylguanidine 10mM * 1mL in DMSO

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