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Harringtonolide

CAT: 0804-HY-N10335-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N10335-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells) . Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities[1].
CAS Number
64761-48-4
UNSPSC
12352005
Target
FAK
Type
Natural Products
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/harringtonolide.html
Purity
98.0
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C(CC2)C3=C([C@H]4C(C5O6)C3[C@@]2([C@H](C)[C@H]5O4)C6=O)C(C)=C1
Molecular Formula
C19H18O4
Molecular Weight
310.34
References & Citations
[1]Zhu TY, et al. Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition. ACS Med Chem Lett. 2022;13 (3) :449-456. Published 2022 Feb 2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
MBS5788326Harringtonolide

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