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Pempidine

CAT: 0804-HY-B1382-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1382-01Size:100 mg
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Description
Pempidine (1,2,2,6,6-Pentamethylpiperidine) is an orally active ganglionic blocking agent used in hypertension-related conditions. Pempidine is a nicotinic receptor blocker. Pempidine can antagonize the nicotine-induced increase of the striatal dopamine (DA) in vitro[1][2][3][4].
CAS Number
79-55-0
Product Name Alternative
1,2,2,6,6-Pentamethylpiperidine
UNSPSC
12352005
Hazard Statement
H226, H301, H315, H319, H335
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Pempidine.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(C)CCCC(C)(C)N1C
Molecular Formula
C10H21N
Molecular Weight
155.28
Precautions
H226, H301, H315, H319, H335
References & Citations
[1]Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254 (1) :45-51.|[2]L. BRETHERICK, Congeners of Pempidine with High Ganglion-blocking Activity. Nature, 1959, 184: 1707-1709) |[3]Haikala, H., & Ahtee, L. (1988) . Antagonism of the nicotine-induced changes of the striatal dopamine metabolism in mice by mecamylamine and pempidine. Naunyn-Schmiedeberg's archives of pharmacology, 338 (2), 169–173.|[4]MUGGLETON, D. F., & READING, H. W. (1959) . Absorption, metabolism and elimination of pempidine in the rat. British journal of pharmacology and chemotherapy, 14 (2), 202–208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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