17-trifluoromethylphenyl trinor Prostaglandin F2α

17-trifluoromethylphenyl trinor Prostaglandin F2α

• CAS Number: 221246-34-0
• UNSPSC Description: A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.
• Target Antigen: Prostaglandin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/17-trifluoromethylphenyl-trinor-prostaglandin-f2α.html
• Smiles: O[C@@H]1[C@@H]([C@H]([C@@H](C1)O)/C=C/[C@H](CCC2=CC(C(F)(F)F)=CC=C2)O)C/C=C\CCCC(O)=O
• Molecular Weight: 456.50
• References & Citations: [1]Sorbera, et al. Travoprost. Drugs Future 25(1), 41-45 (2000).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported