Aurantiamide

• Description:

  Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Mixed Lineage Kinase; NF-κB; RIP kinase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; MAPK/ERK Pathway; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/aurantiamide.html

• Purity:

  99.56

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(N[C@H](CO)CC1=CC=CC=C1)[C@@H](NC(C2=CC=CC=C2)=O)CC3=CC=CC=C3

• Molecular Formula:

  C25H26N2O3

• Molecular Weight:

  402.49

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]He RB, et al. Aurantiamide mitigates acute kidney injury by suppressing renal necroptosis and inflammation via GRPR-dependent mechanism.|[2]Shen H, et al. Aurantiamide suppresses the activation of NLRP3 inflammasome to improve the cognitive function and central inflammation in mice with Alzheimer's disease. CNS Neurosci Ther. 2023 Apr;29 (4) :1075-1085.|[3]Shen H, et al. Aurantiamide promotes M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimer's disease. Phytother Res. 2023 Jan;37 (1) :101-110.|[4]Aslan M, et al. Effects of aurantiamide on a rat model of renovascular arterial hypertension. Pflugers Arch. 2023 Oct;475 (10) :1177-1192.|[5]Lijiang Chen, et al. Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats After Oral Administration of Portulaca Oleracea L. Extracts. J Agric Food Chem. 2016 May 4;64 (17) :3445-55.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  NF-κB; RIPK3

• CAS Number:

  58115-31-4