GLPG2737

CAT: 0804-HY-158144Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-158144Size:1 Each
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Description
GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis[1].
CAS Number
[2093974-63-9]
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/glpg2737.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(N(C)C)=O)C1=NC2=C(C(C3CCC3)=NN2C4=CC=C(C=C4)F)C(N(CC5)CCC5N(CC6)CCC6OC)=C1
Molecular Formula
C30H40FN7O4S
Molecular Weight
613.75
References & Citations
[1]Pizzonero M, et al. Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector. J Med Chem. 2024 Apr 11;67 (7) :5216-5232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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