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GLPG2737

CAT: 0804-HY-158144Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158144Size:1 Each
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Description
GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis[1].
CAS Number
2093974-63-9
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/glpg2737.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(N(C)C)=O)C1=NC2=C(C(C3CCC3)=NN2C4=CC=C(C=C4)F)C(N(CC5)CCC5N(CC6)CCC6OC)=C1
Molecular Formula
C30H40FN7O4S
Molecular Weight
613.75
References & Citations
[1]Pizzonero M, et al. Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector. J Med Chem. 2024 Apr 11;67 (7) :5216-5232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

7MK589F6SC
CAS Number2093974-63-9
PubChem CID126742266
IUPAC Name3-cyclobutyl-N-(dimethylsulfamoyl)-1-(4-fluorophenyl)-4-[4-(4-methoxypiperidin-1-yl)piperidin-1-yl]pyrazolo[5,4-b]pyridine-6-carboxamide
Molecular FormulaC30H40FN7O4S
Molecular Weight613.7
XLogP3.9
Topological Polar Surface Area121
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Heavy Atom Count43
Formal Charge0
Complexity1050
SMILES
CN(C)S(=O)(=O)NC(=O)C1=NC2=C(C(=C1)N3CCC(CC3)N4CCC(CC4)OC)C(=NN2C5=CC=C(C=C5)F)C6CCC6
InChI
InChI=1S/C30H40FN7O4S/c1-35(2)43(40,41)34-30(39)25-19-26(37-15-11-22(12-16-37)36-17-13-24(42-3)14-18-36)27-28(20-5-4-6-20)33-38(29(27)32-25)23-9-7-21(31)8-10-23/h7-10,19-20,22,24H,4-6,11-18H2,1-3H3,(H,34,39)
InChIKey
JPIAJLPRTOWAEC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7MK589F6SC
CAS: 2093974-63-9
CID: 126742266
Formula: C30H40FN7O4S
MW: 613.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight613.7
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass613.28465212
Monoisotopic Mass613.28465212
Topological Polar Surface Area121 Ų
Heavy Atom Count43
Formal Charge0
Complexity1050
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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