Danicopan

CAT: 0804-HY-117930-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-117930-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) [1].
CAS Number
[1903768-17-1]
Product Name Alternative
ACH-4471
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/danicopan.html
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)C[C@H](F)C1)NC5=NC(Br)=CC=C5
Molecular Formula
C26H23BrFN7O3
Molecular Weight
580.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102 (3) :466-475.|[2]Boyer DD, Ko YP, Podos SD, et al. Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies. Transl Vis Sci Technol. 2022;11 (10) :37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
BA5882-10Danicopan
A18609-5Danicopan 5mg
A18609-25Danicopan 25mg
A18609-1Danicopan 1mg
A18609-2Danicopan 2mg
A18609-10Danicopan 10mg
A18609-50Danicopan 50mg
A18609-100Danicopan 100mg
207093Danicopan free base
A18609-10mM-DDanicopan 10mM * 1mL in DMSO

Popular Products