IRAK inhibitor 4
CAT:
804-HY-13278-02
Size:
5 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IRAK inhibitor 4
- CAS Number: 1012104-68-5
- UNSPSC Description: IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
- Target Antigen: IRAK
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/IRAK-inhibitor-4.html
- Purity: 99.77
- Solubility: DMSO : 12.5 mg/mL (ultrasonic)
- Smiles: OC1CCC(N2C3=C(C=C(C=C3)C(NCCC(C)C)=O)N=C2NC4=NNC5=C4C=C(C=C5)C6=CC=CC=C6OC(F)(F)F)CC1
- Molecular Weight: 620.66
- References & Citations: [1]Marinho FV, et al. Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection. J Immunol. 2016 Sep 1;197(5):1852-63.|[2]Talreja J, et al. Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells. J Immunol. 2016 Aug 15;197(4):1368-78.|[3]Li Z, et al. Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest. 2015 Mar 2;125(3):1081-97.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported