RSK4-IN-1 (TFA)

RSK4-IN-1 (TFA)

• UNSPSC Description: RSK4-IN-1 TFA is a potent RSK4 inhibitor with a IC50 value of 9.5 nM. RSK4-IN-1 TFA has antitumor activity[1].
• Target Antigen: Ribosomal S6 Kinase (RSK)
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/rsk4-in-1-tfa.html
• Purity: 99.32
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: CC(C)(C1=CN=C(N=C1N2C3CCCC3)NC4=CC(F)=C(C(F)=C4)O)OC2=O.O=C(O)C(F)(F)F
• Molecular Weight: 504.41
• References & Citations: [1]Yuan Y, et al. Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma. J Med Chem. 2021 Sep 23;64(18):13572-13587.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported