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Diphenylcyclopropenone

CAT: 0804-HY-W014605-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W014605-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diphenylcyclopropenone (Diphencyprone) is a potent hapten acting as a topical immunomodulatory agent, which induces an allergic contact dermatitis. Diphenylcyclopropenone induces an increase of cell-surface thiols in cells of a human monocytic cell line, THP-1. Diphenylcyclopropenone acts on the autoreactive T-lymphocytes within the follicular milieu to induce Apoptosis. Diphenylcyclopropenone can be used for alopecia areata research[1][2][3][4].
CAS Number
886-38-4
Product Name Alternative
Diphencyprone
UNSPSC
12352005
Hazard Statement
H317
Target
Apoptosis; Interleukin Related; IRE1; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/diphenylcyclopropenone.html
Purity
99.95
Solubility
Acetone : ≥ 50 mg/mL|DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=CC=C2)=C1C3=CC=CC=C3
Molecular Formula
C15H10O
Molecular Weight
206.24
Precautions
H317
References & Citations
[1]Yugang Gong, et al. Diphenylcyclopropenone plays an effective therapeutic role by up-regulating the TSLP/OX40L/IL-13 pathway in severe alopecia areata. Exp Dermatol. 2021 Feb;30 (2) :278-283.|[2]Zekayi Kutlubay, et al. Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata. Turk J Med Sci. 2020 Dec 17;50 (8) :1817-1824.|[3]Hirota M, et al. Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone. J Toxicol Sci. 2010 Dec;35 (6) :871-9.|[4]Svalgaard JD, et al. Systemic immunogenicity of para-Phenylenediamine and Diphenylcyclopropenone: two potent contact allergy-inducing haptens. Immunol Res. 2014 Jan;58 (1) :40-50.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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CatalogName
T21444-01Diphenylcyclopropenone
D50300-01Diphenylcyclopropenone 98%

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