Valproic acid (Standard)

• Description:

  Valproic acid (Dipropylacetic Acid) (Standard) is an analytical standard for valproic acid. This product is intended for research and analytical applications. Valproic acid is an orally active HDAC inhibitor (IC50=0.5-2 mM), inhibits the activity of HDAC1 (IC50=400 μM), and induces the degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits the proliferation of small cell lung cancer (SCLC) cells. Valproic acid is used in the study of epilepsy, bipolar disorder, metabolic diseases, HIV infection, and migraine[1][2][3][4][5][6][7].

• Product Name Alternative:

  VPA (Standard) ; 2-Propylpentanoic acid (Standard) ; Dipropylacetic acid (Standard)

• UNSPSC:

  12352211

• Target:

  Apoptosis; Autophagy; Endogenous Metabolite; HDAC; HIV; Mitophagy; Notch; Organoid; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/valproic-acid-standard.html

• Purity:

  99.97

• Smiles:

  CCCC(CCC)C(O)=O

• Molecular Formula:

  C8H16O2

• Molecular Weight:

  144.21

• References & Citations:

  [1]Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30 (6) :2999-3005.|[2]Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276 (39) :36734-41.|[3]Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.|[4]Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31 (8) :740-50.|[5]Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85 (1) :1-10.|[6]Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148 (1) :31-7.|[7]Routy JP, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med. 2012 May;13 (5) :291-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC; HDAC1; HDAC2

• CAS Number:

  [99-66-1]