VMIP-II (1-21)

• Description:

  VMIP-II (1-21) (NT21MP) is an inhibitor of CXCR4. vMIP-II (1-21) interacts broadly with CC and CXC chemokine receptors. vMIP-II (1-21) inhibits CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM) [1].

• Product Name Alternative:

  NT21MP; V1 peptide

• UNSPSC:

  12352209

• Target:

  CXCR

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/vmip-ii-1-21.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N1[C@@H] (CCC1) C (N[C@@H] (CC (O) =O) C (N[C@@H] (CCCCN) C (N[C@@H] (CS) C (N[C@@H] (CS) C (N[C@@H] (CC (C) C) C (NCC (N[C@H] (C (N[C@@H] (CCC (N) =O) C (N[C@@H] (CCCCN) C (N[C@@H] (CCCNC (N) =N) C (N2[C@@H] (CCC2) C (N[C@@H] (CC (C) C) C (N3[C@@H] (CCC3) C (O) =O) =O) =O) =O) =O) =O) =O) CC4=CC=C (C=C4) O) =O) =O) =O) =O) =O) =O) =O) [C@H] (CCCNC (N) =N) NC ([C@H] (CC5=CN=CN5) NC ([C@@H] (NC ([C@H] (CO) NC ([C@H] (C) NC (CNC ([C@@H] (N) CC (C) C) =O) =O) =O) =O) CC6=CNC7=CC=CC=C67) =O) =O

• Molecular Formula:

  C108H169N33O27S2

• Molecular Weight:

  2425.84

• References & Citations:

  [1]Zhou N, ey al. A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II. Biochemistry. 2000 Apr 4;39 (13) :3782-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  265650-93-9