Monoclonal Anti-Eribulin Antibody, Rabbit IgG (1M1G11)

Monoclonal Anti-Eribulin Antibody, Rabbit IgG (1M1G11)

• Background: Eribulin is a synthetic analogue of the macrocyclic polyether halichondrin B, which was originally isolated from the Asian sea sponge Halichondria okadai. Eribulin binds specifically to the β-tubulin subunit on the (+) end of the microtubule and potently inhibits elongation of the formed microtubule, while having little or no effect on microtubule depolymerization. Eribulin's potent antimitotic activity and nonmitotic effects on tumor biology make it an interesting candidate for investigation as a MTA payload for ADCs.
• Description: Eribulin is a synthetic analogue of the macrocyclic polyether halichondrin B, which was originally isolated from the Asian sea sponge Halichondria okadai. Eribulin binds specifically to the β-tubulin subunit on the (+) end of the microtubule and potently inhibits elongation of the formed microtubule, while having little or no effect on microtubule depolymerization. Eribulin's potent antimitotic activity and nonmitotic effects on tumor biology make it an interesting candidate for investigation as a MTA payload for ADCs.
• Host: HEK 293
• Origin Species: Rabbit
• Target: Eribulin
• Conjugation: Unconjugated
• Tag: Rabbit IgG | Rabbit Kappa
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower._x000D_Please avoid repeated freeze-thaw cycles.
• Purity: 90%
• Bioactivity: Immobilized Monoclonal Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-MY2012b) at 1 μg/mL (100 μL/well) can bind Farletuzumab Ecteribulin diluted with 100% Mouse Serum with a linear range of 0.02-1.25 μg/mL (Routinely tested).
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C