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Nelivaptan

CAT: 0804-HY-10066-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10066-01Size:1 mg
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Description
Nelivaptan (SSR-149415) is a selective and orally active vasopressin V1b receptor antagonist (Ki: 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively) . Nelivaptan inhibits arginine vasopressin (AVP) -induced Ca2+ increase and corticotropin secretion. Nelivaptan can be used for research of stress, anxiety and depression[1][2].
CAS Number
439687-69-1
Product Name Alternative
SSR-149415
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nelivaptan.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(N(C(C=C1)=C2C=C1Cl)C([C@@]2(C3=CC=CC=C3OC)N4[C@@H](C[C@@H](O)C4)C(N(C)C)=O)=O)(C(C(OC)=C5)=CC=C5OC)=O
Molecular Formula
C30H32ClN3O8S
Molecular Weight
630.11
Precautions
H302, H315, H319
References & Citations
[1]Serradeil-Le Gal C, et al. Characterization of (2S,4R) -1-[5-chloro-1-[ (2,4-dimethoxyphenyl) sulfonyl]-3- (2-methoxy-phenyl) -2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N, N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist. J Pharmacol Exp Ther. 2002 Mar;300 (3) :1122-30.|[2]Bessa JM, et al. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol Psychiatry. 2009 Aug;14 (8) :764-73, 739.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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CatalogName
BUP07358-01Nelivaptan

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