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Isoquinoline

CAT: 0804-HY-W012732-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W012732-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities[1][2][3][4][5][6].
CAS Number
119-65-3
UNSPSC
12352005
Hazard Statement
H302, H311, H315, H319, H412
Target
Drug Isomer; HIV; Interleukin Related; NF-κB; Parasite; TNF Receptor
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; NF-κB; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/isoquinoline.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C12=C(C=NC=C2)C=CC=C1
Molecular Formula
C9H7N
Molecular Weight
129.16
Precautions
H302, H311, H315, H319, H412
References & Citations
[1] Zhi-Xing Qing, et al. Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and Their Structure-activity Relationship. Curr Med Chem|[2]Iwasa K, et al. Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents. Bioorg Med Chem. 2001 Nov;9 (11) :2871-84.|[3]Pesarico AP, et al. A novel isoquinoline compound abolishes chronic unpredictable mild stress-induced depressive-like behavior in mice. Behav Brain Res. 2016 Jul 1;307:73-83.|[4]Chueh W H, et al. Protective effect of isoquinoline alkaloid berberine on spontaneous inflammation in the spleen, liver and kidney of non-obese diabetic mice through downregulating gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines[J]. Food Chemistry, 2012, 131 (4) : 1263-1271.|[5]Wright CW, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63 (12) :1638-40.|[6]Kim M, et al. Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway. Int Neurourol J. 2014 Sep;18 (3) :115-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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