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Etanercept

CAT: 0804-HY-108847-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108847-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].
CAS Number
185243-69-0
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; TNF Receptor
Type
Inhibitory Antibodies
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Etanercept.html
Purity
99.20
Solubility
H2O
Smiles
[Etanercept]
Molecular Weight
(102.5 kDa)
Precautions
H302, H315, H319, H335
References & Citations
[1]Goffe B, et al. Etanercept: An overview. J Am Acad Dermatol. 2003;49 (2 Suppl) :S105-S111.|[2]Goldenberg MM. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin Ther. 1999;21 (1) :75-2.|[3]Totoson P, et al. Etanercept improves endothelial function via pleiotropic effects in rat adjuvant-induced arthritis. Rheumatology (Oxford) . 2016;55 (7) :1308-1317.|[4]Haraoui B, et al. Etanercept in the treatment of rheumatoid arthritis. Ther Clin Risk Manag. 2007;3 (1) :99-105.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Isoform
TNFRSF5/CD40; TNFRSF6/Fas/CD95

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