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VU0650786

CAT: 0804-HY-108710-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108710-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].
CAS Number
1809085-30-0
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0650786.html
Concentration
10mM
Purity
99.55
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
ClC1=CN=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)C=C1
Molecular Formula
C18H15ClFN5O2
Molecular Weight
387.80
References & Citations
[1]Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58 (18) :7485-500.|[2]Max E Joffe, et al. mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects. Neuron. 2020 Jan 8;105 (1) :46-59.e3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR3

Alternative Products

CatalogName
MBS5754118VU0650786
A19689-100VU0650786 100mg
A19689-25VU0650786 25mg
A19689-5VU0650786 5mg
A19689-50VU0650786 50mg
A19689-10VU0650786 10mg
A19689-1VU0650786 1mg
A19689-10mM-DVU0650786 10mM * 1mL in DMSO

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